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5-α 환원효소'를 억제해 여성형 탈모를 유발하는 '다이하이드로테스토스테론(dihydrotestosterone, DHT)'의 유발을 저지함으로써 탈모를 치료하는 기전이다. 여성형 탈모 병자 대다수가 처방받는 약으로, 국내 남성형 탈모치료제 시장은 약 700억 원에 이른다.
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만성 스트레스가 모낭(hair follicle) 줄기세포의 재생 기능을 방해하는 생물학적 메커니즘을 미국 하버드대 연구진이 밝혀냈다. 스트레스를 받을 때 분비되는 호르몬이, 모낭 줄기세포의 휴지기(rest phase)를 연장해 재생을 장시간 멈추게 하는 것으로 보여졌다.
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